Effective omalizumab treatment influenced eosinophil function in severe allergic asthmatics.

ABSTRACT:

Background

Omalizumab is an effective anti-immunoglobulin E (IgE) treatment for allergic asthma. Eosinophil plays a critical role in the pathogenesis of allergic airway inflammation. This study aimed to explore the influence of effective omalizumab treatment on circulating eosinophils.

Methods

Allergic asthmatics enrolled in the study were treated with omalizumab for at least 16 weeks and exhibited a good or excellent response according to the global evaluation of treatment effectiveness (GETE) assessed by each patient and specialist physician. For eosinophil functional evaluation, peripheral blood eosinophils were separated; and examined the expression of human leukocyte antigen (HLA)-DR and co-stimulatory molecules cluster of differentiation (CD) 80, CD86 and CD40 by Flow

SUBMITTER: Yan H 

PROVIDER: S-EPMC10323569 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature