Relationship between PD-L1 expression and molecular aberrances in lung adenocarcinoma with solid components.

ABSTRACT:

Background

Previous studies have evaluated the expression of programmed cell death ligand 1 (PD-L1) in terms of genetic mutation in lung adenocarcinoma (LUAD). However, there are no corresponding large-sample studies in Chinese patients with LUAD with solid components (LUAD-SC). Furthermore, it remains unknown whether the relationship that exists between PD-L1 expression levels and clinicopathological and molecular profiles in small biopsy specimens is consistent with that in surgically-resected specimens. The present study explored the clinicopathological features and genetic correlation of PD-L1 expression in LUAD-SC.

Methods

We collected 1,186 LUAD-SC specimens from Fudan University, Zhongshan Hospital. The tumors were divided into PD-L1 negative, low, and high groups acc

SUBMITTER: Zhu K 

PROVIDER: S-EPMC10323584 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature