Clinical pharmacokinetic study of tacrolimus in continuous intravenous administration for lung transplantation.

ABSTRACT: Tacrolimus is a cornerstone of immunosuppression after lung transplantation. However, there are no clear guidelines on how to administer the drug and the duration to achieve the required therapeutic range in the early phase of lung transplantation. This is a single-center cohort study of adult patients who had lung transplantation. Tacrolimus was administered beginning with a low dose of 0.01 mg/kg/day immediately after transplantation. In addition, the designated clinical pharmacist conducted a daily intervention with trough concentrations to achieve the target of 10-15 ng/mL. Time in the therapeutic range (TTR_in, %), time to the therapeutic range (TTR_to, days), and coefficient of variation (CoV) of tacrolimus were evaluated for the 2-week post-transplant period. A t

SUBMITTER: Sohn YM 

PROVIDER: S-EPMC10323585 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature