Retrospective on global pulmonary hypertension clinical trials: 1999-2021.

ABSTRACT:

Background

Data are quite sparse on the comprehensive analyses of pulmonary hypertension (PH) clinical trials worldwide.

Methods

Information including participating countries (developed or developing), intervention type, trial size, PH categories, sponsorship, study phase, design strategies, and participants' demographic characteristics was extracted from PH trials registered on ClinicalTrials.gov from 1999 to 2021.

Results

A total of 203 eligible clinical PH trials were screened, involving 23,402 participants, 67.8% of whom were females. Major clinical trials were designed to test drug interventions (95.6%), sponsored solely by industries in 59.5%, and targeting Group 1 PH patients in 76.3%. A large number of countries participated in PH clinical trials; however, mos

SUBMITTER: Zheng L 

PROVIDER: S-EPMC10323586 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature