The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysis.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory skin disease. Dyslipidemia may be a risk factor of psoriasis. But the causal relationship between psoriasis and blood lipid still remains uncertain.

Methods

The two data of blood lipid were obtained from UK Biobank (UKBB) and Global Lipid Genetics Consortium Results (GLGC). The primary and secondary database were from large publicly available genome-wide association study (GWAS) with more than 400,000 and 170,000 subjects of European ancestry, respectively. The psoriasis from Finnish biobanks of FinnGen research project for psoriasis, consisting of 6,995 cases and 299,128 controls. The single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) were used to assess the total and direct effects

SUBMITTER: Zhang ZY 

PROVIDER: S-EPMC10323678 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature