Dataset Information

A long noncoding RNA-microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas.

ABSTRACT:

Purpose

In hopes of discovering new markers for metastatic or aggressive phenotypes of pheochromocytomas and paragangliomas (PCPG), we analyzed the noncoding transcriptome from patient gene expression data in The Cancer Genome Atlas.

Methods

Differential expression of miRNAs was observed between PCPG molecular subtypes. We specifically characterized candidate miRNAs that are upregulated in pseudohypoxic PCPGs with mutations in succinate dehydrogenase complex subunits, B and/or D (SDHB and/or SDHD, respectively), which are mutations associated with unfavorable clinical outcomes.

Results

Our computational analysis identified four candidate miRNAs that showed elevated expression in metastatic compared to non-metastatic PCPGs: miR-182, miR-183, miR-96, and miR-383. We also found six candidate lncRNAs harboring opposite expression patterns from the miRNAs when we analyzed the expression profiles of their predicted target lncRNAs. Three of these lncRNA candidates, USP3-AS1, LINC00877, and AC009312.1, were validated to have reduced expression in metastatic compared to non-metastatic PCPGs. Finally, using univariate and multivariate analysis, we found miRNA miR-182 to be an independent predictor of metastasis-free survival in PCPGs.

Conclusions

We identified candidate miRNA and lncRNAs associated with metastasis-free survival in PCPGs.

SUBMITTER: Ghosal S

PROVIDER: S-EPMC10323688 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

A long noncoding RNA-microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas.

Ghosal Suman S Zhu Boqun B Huynh Thanh-Truc TT Meuter Leah L Jha Abhishek A Talvacchio Sara S Knue Marianne M Patel Mayank M Prodanov Tamara T Das Shaoli S Zeiger Martha A MA Nilubol Naris N Shankavaram Uma T UT Taieb David D Pacak Karel K

Endocrine 20210918 1

<h4>Purpose</h4>In hopes of discovering new markers for metastatic or aggressive phenotypes of pheochromocytomas and paragangliomas (PCPG), we analyzed the noncoding transcriptome from patient gene expression data in The Cancer Genome Atlas.<h4>Methods</h4>Differential expression of miRNAs was observed between PCPG molecular subtypes. We specifically characterized candidate miRNAs that are upregulated in pseudohypoxic PCPGs with mutations in succinate dehydrogenase complex subunits, B and/or D ( ...[more]

PMID: 34536193

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Dataset Information

A long noncoding RNA-microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas.

Purpose

Methods

Results

Conclusions

Publications

A long noncoding RNA-microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas.

Similar Datasets

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