Characteristics and outcomes of autoimmune hemolytic anemia after pediatric allogeneic stem cell transplant.

ABSTRACT:

Background

Autoimmune hemolytic anemia (AIHA) after allogeneic hematopoietic stem cell transplant (HSCT) is a rare but complex and serious complication. Detailed descriptions of cases and management strategies are needed due to lack of prospective trials.

Objectives

Describe the incidence, clinical characteristics, and management of AIHA after HSCT in a pediatric cohort.

Methods

This is a retrospective cohort study of 33 pediatric patients with AIHA after HSCT at an academic tertiary care center from 2003 to 2019.

Results

The overall incidence of AIHA after allogeneic HSCT was 3.8% (33/868). AIHA was significantly more common after transplant for nonmalignant versus malignant diagnoses (7.0% [26/370] vs. 1.4% [7/498], p < .0001). AIHA developed at a median of 4

SUBMITTER: Hillier K 

PROVIDER: S-EPMC10323689 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature