Identification of anti-cyanobacterial leads targeting carbonic anhydrase from phytochemical database using in silico approach.

ABSTRACT: In cyanobacteria, carbonic anhydrase (zinc metalloenzyme) is a major enzyme that converts CO₂ to HCO₃- maintaining the carbon concentration around the vicinity of RuBisCo, leading to cyanobacterial biomass generation. Anthropogenic activities, disposal of leached micro nutrients effluents from industries into the aquatic environment results in cyanobacterial blooms. The harmful cyanobacteria release cyanotoxins in open-water system which on ingression through oral route causes major health issues like hepatotoxicity and immunotoxicity. A database was prepared consisting of approximately 3k phytochemicals curated from previous literatures, earlier identified by GC-MS analysis. The phytochemicals were subjected to online servers to identify the novel lead molecules whic

SUBMITTER: Padhiary A 

PROVIDER: S-EPMC10323741 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature