Potent antifungal properties of gallic acid in Sarcochlamys pulcherrima against Candida auris.

ABSTRACT: Candida auris is a major public health concern due to its high transmission and mortality rates, as well as the emergence of pan-resistant strains. This study aimed to identify an antifungal compound from Sarcochlamys pulcherrima , an ethnomedicinal plant, that can inhibit the growth of C. auris. Methanol and ethyl acetate extracts of the plant were obtained, and high-performance thin-layer chromatography (HPTLC) analysis was conducted to identify the major compounds in the extracts. The major compound detected by HPTLC was subjected to in vitro antifungal activity testing, and its antifungal mechanism was determined. The plant extracts inhibited the growth of both C. auris and Candida albicans. HPTLC analysis revealed the presence of gallic acid i

SUBMITTER: Akhtar N 

PROVIDER: S-EPMC10323742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature