PD-L1 and tumor-infiltrating CD8⁺ lymphocytes are correlated with clinical characteristics in pediatric and adolescent pituitary adenomas.

ABSTRACT:

Objective

To investigate the levels of tumor-infiltrating CD8⁺ lymphocytes (CD8⁺ TILs) and the expression of programmed cell death receptor ligand 1 (PD-L1) in the tumor microenvironment (TME) of pediatric and adolescent pituitary adenomas (PAPAs) and analyze the correlation between their levels and the clinical characteristics.

Methods

A series of 43 PAPAs cases were enrolled over a period of 5 years. To compare the TME of PAPAs and adult PAs, 43 PAPAs cases were matched with 60 adult PAs cases (30 cases were between 20 and 40 years old, and 30 cases were older than 40 years) for main clinical characteristics. The expression of immune markers in PAPAs was detected by immunohistochemistry, and their correlation with the clinical outcomes was analyzed us

SUBMITTER: Shi M 

PROVIDER: S-EPMC10323746 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature