Is increased myocardial triglyceride content associated with early changes in left ventricular function? A ¹H-MRS and MRI strain study.

ABSTRACT:

Background

Type 2 diabetes (T2D) and obesity induce left ventricular (LV) dysfunction. The underlying pathophysiological mechanisms remain unclear, but myocardial triglyceride content (MTGC) could be involved.

Objectives

This study aimed to determine which clinical and biological factors are associated with increased MTGC and to establish whether MTGC is associated with early changes in LV function.

Methods

A retrospective study was conducted using five previous prospective cohorts, leading to 338 subjects studied, including 208 well-phenotyped healthy volunteers and 130 subjects living with T2D and/or obesity. All the subjects underwent proton magnetic resonance spectroscopy and feature tracking cardiac magnetic resonance imaging to measure myocardial strain.

Resu

SUBMITTER: Soghomonian A 

PROVIDER: S-EPMC10323751 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature