Association Between Stimulant Treatment and Substance Use Through Adolescence Into Early Adulthood.

ABSTRACT:

Importance

Possible associations between stimulant treatment of attention-deficit/hyperactivity disorder (ADHD) and subsequent substance use remain debated and clinically relevant.

Objective

To assess the association of stimulant treatment of ADHD with subsequent substance use using the Multimodal Treatment Study of ADHD (MTA), which provides a unique opportunity to test this association while addressing methodologic complexities (principally, multiple dynamic confounding variables).

Design, setting, and participants

MTA was a multisite study initiated at 6 sites in the US and 1 in Canada as a 14-month randomized clinical trial of medication and behavior therapy for ADHD but transitioned to a longitudinal observational study. Participants were recruited between 1994 a

SUBMITTER: Molina BSG 

PROVIDER: S-EPMC10323757 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature