Multi-Omics Studies in Historically Excluded Populations: The Road to Equity.

ABSTRACT: Over the past few decades, genomewide association studies (GWASs) have identified the specific genetics variants contributing to many complex diseases by testing millions of genetic variations across the human genome against a variety of phenotypes. However, GWASs are limited in their ability to uncover mechanistic insight given that most significant associations are found in non-coding region of the genome. Furthermore, the lack of diversity in studies has stymied the advance of precision medicine for many historically excluded populations. In this review, we summarize most popular multi-omics approaches (genomics, transcriptomics, proteomics, and metabolomics) related to precision medicine and highlight if diverse populations have been included and how their findings have advance biologi

SUBMITTER: Yang G 

PROVIDER: S-EPMC10323857 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature