Ectopic lymphoid structures in the aged lacrimal glands.

ABSTRACT: Aging is a complex biological process in which many organs are pathologically affected. We previously reported that aged C57BL/6J had increased lacrimal gland (LG) lymphoid infiltrates that suggest ectopic lymphoid structures. However, these ectopic lymphoid structures have not been fully investigated. Using C57BL/6J mice of different ages, we analyzed the transcriptome of aged murine LGs and characterized the B and T cell populations. Age-related changes in the LG include increased differentially expressed genes associated with B and T cell activation, germinal center formation, and infiltration by marginal zone-like B cells. We also identified an age-related increase in B1⁺ cells and CD19⁺B220⁺ cells. B220⁺CD19⁺ cells were GL7^+<

SUBMITTER: Galletti JG 

PROVIDER: S-EPMC10323865 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature