Insulin-cobalt core-shell nanoparticles for receptor-targeted bioimaging and diabetic wound healing.

ABSTRACT: Diabetic wounds represent a major issue in medical care and need advanced therapeutic and tissue imaging systems for better management. The utilization of nano-formulations involving proteins like insulin and metal ions plays significant roles in controlling wound outcomes by decreasing inflammation or reducing microbial load. This work reports the easy one-pot synthesis of extremely stable, biocompatible, and highly fluorescent insulin-cobalt core-shell nanoparticles (ICoNPs) with enhanced quantum yield for their highly specific receptor-targeted bioimaging and normal and diabetic wound healing in vitro (HEKa cell line). The particles were characterized using physicochemical properties, biocompatibility, and wound healing applications. FTIR bands at 670.35 cm^-1, 849.79,

SUBMITTER: Sharda D 

PROVIDER: S-EPMC10323873 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature