Molecular profiling and treatment pattern differences between intrahepatic and extrahepatic cholangiocarcinoma.

ABSTRACT:

Background

Treatment patterns for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) differ, but limited studies exist comparing them. This study examines differences in molecular profiling rates and treatment patterns in these populations, focusing on use of adjuvant, liver-directed, targeted, and investigational therapies.

Methods

This multicenter collaboration included patients with ICC or ECC treated at 1 of 8 participating institutions. Retrospective data were collected on risk factors, pathology, treatments, and survival. Comparative statistical tests were 2-sided.

Results

Among 1039 patients screened, 847 patients met eligibility (ICC = 611, ECC = 236). Patients with ECC were more likely than those with ICC to present with early sta

SUBMITTER: Spencer K 

PROVIDER: S-EPMC10323903 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature