Atomic-Scale Resolution Insights into Structural and Dynamic Differences between Ofloxacin and Levofloxacin.

ABSTRACT: This study employs advanced solid-state NMR techniques to investigate the atomic-level structure and dynamics of two enantiomers: ofloxacin and levofloxacin. The investigation focuses on critical attributes, such as the principal components of the chemical shift anisotropy (CSA) tensor, the spatial proximity of ¹H and ¹³C nuclei, and site-specific ¹³C spin-lattice relaxation time, to reveal the local electronic environment surrounding specific nuclei. Levofloxacin, the levo-isomer of ofloxacin, exhibits higher antibiotic efficacy than its counterpart, and the dissimilarities in the CSA parameters indicate significant differences in the local electronic configuration and nuclear spin dynamics between the two enantiomers. Additionally, the study employs the <

SUBMITTER: Pradhan BL 

PROVIDER: S-EPMC10323956 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature