Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis.

ABSTRACT: Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is characterized by fibroblast proliferation, activation, and invasion and extracellular matrix accumulation. Lung fibroblast heterogeneity is well recognized. With single-cell RNA sequencing, fibroblast subtypes have been reported by recent studies. However, the roles of fibroblast subtypes in effector functions in lung fibrosis are not well understood. In this study, we incorporated the recently published single-cell RNA-sequencing datasets on murine lung samples of fibrosis models and human lung samples of fibrotic diseases and analyzed fibroblast gene signatures. We identified and confirmed the novel fibroblast subtypes we reported recently across all samples of both mouse models and human lung fibro

SUBMITTER: Liu X 

PROVIDER: S-EPMC10324043 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature