Theoretical Study on the Mechanism of Cobalt-Catalyzed C-O Silylation and Stannylation.

ABSTRACT: Organosilicon and organotin compounds have been widely used in many fields, such as organic synthesis, materials science, and biochemistry, because of their unique physical and electronic properties. Recently, two novel compounds containing C-Si or C-Sn bonds have been synthesized. These compounds can be used for late modification of drug-like molecules such as probenecid, duloxetine, and fluoxetine derivatives. However, the detailed reaction mechanisms and the influencing factors that determine selectivity are still unclear. Moreover, several questions remain that are valuable to investigate further, such as (1) the influence of the solvent and the lithium salt on the reaction of the Si/Sn-Zn reagent, (2) the stereoselective functionalization of C-O bonds, and (3) the differences between

SUBMITTER: Cui CX 

PROVIDER: S-EPMC10324068 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature