Evolution of Sequence and Structure of SARS-CoV-2 Spike Protein: A Dynamic Perspective.

ABSTRACT: Novel coronavirus (SARS-CoV-2) enters its host cell through a surface spike protein. The viral spike protein has undergone several modifications/mutations at the genomic level, through which it modulated its structure-function and passed through several variants of concern. Recent advances in high-resolution structure determination and multiscale imaging techniques, cost-effective next-generation sequencing, and development of new computational methods (including information theory, statistical methods, machine learning, and many other artificial intelligence-based techniques) have hugely contributed to the characterization of sequence, structure, function of spike proteins, and its different variants to understand viral pathogenesis, evolutions, and transmission. Laying on the foundation

SUBMITTER: Sinha A 

PROVIDER: S-EPMC10324094 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature