Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1.

ABSTRACT:

Background

Following solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a challenge due to its narrow therapeutic index and its high inter- and intra-pharmacokinetic (PK) variability. As the contribution of the gut microbiota to drug metabolism is now emerging, it might be explored as one of the factors explaining TAC PK variability. Herein, we explored the consequences of TAC administration on the gut microbiota composition. Reciprocally, we studied the contribution of the gut microbiota to TAC PK, using a combination of in vivo and in vitro models.

Results

TAC oral administration in mice resulted in compositional alterations of the gut microbiota, namely lower evenness and disturbance in the relative ab

SUBMITTER: Degraeve AL 

PROVIDER: S-EPMC10324113 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature