Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences.

ABSTRACT:

Background

Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes and produced through transcription and splicing of their host. Intronic snoRNAs were long viewed as inert passengers with little effect on host expression. However, a recent study reported a snoRNA influencing the splicing and ultimate output of its host gene. Overall, the general contribution of intronic snoRNAs to host expression remains unclear.

Results

Computational analysis of large-scale human RNA-RNA interaction datasets indicates that 30% of detected snoRNAs interact with their host transcripts. Many snoRNA-host duplexes are located near alternatively spliced exon

SUBMITTER: Bergeron D 

PROVIDER: S-EPMC10324135 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature