Starting a conversation about estimands with public partners involved in clinical trials: a co-developed tool.

ABSTRACT:

Background

Clinical trials aim to draw conclusions about the effects of treatments, but a trial can address many different potential questions. For example, does the treatment work well for patients who take it as prescribed? Or does it work regardless of whether patients take it exactly as prescribed? Since different questions can lead to different conclusions on treatment benefit, it is important to clearly understand what treatment effect a trial aims to investigate-this is called the 'estimand'. Using estimands helps to ensure trials are designed and analysed to answer the questions of interest to different stakeholders, including patients and public. However, there is uncertainty about whether patients and public would like to be involved in defining estimands and how to do so

SUBMITTER: Cro S 

PROVIDER: S-EPMC10324181 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature