Identification of lipid metabolism-related biomarkers for diagnosis and molecular classification of atherosclerosis.

ABSTRACT:

Background

Atherosclerosis is now the main cause of cardiac-cerebral vascular diseases around the world. Disturbances in lipid metabolism have an essential role in the development and progression of atherosclerosis. Thus, we aimed to investigate lipid metabolism-related molecular clusters and develop a diagnostic model for atherosclerosis.

Methods

First, we used the GSE100927 and GSE43292 datasets to screen differentially expressed lipid metabolism-related genes (LMRGs). Subsequent enrichment analysis of these key genes was performed using the Metascape database. Using 101 atherosclerosis samples, we investigated the LMRG-based molecular clusters and the corresponding immune cell infiltration. After that, a diagnostic model for atherosclerosis was constructed using the least

SUBMITTER: Pan X 

PROVIDER: S-EPMC10324206 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature