Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure.

ABSTRACT:

Background

Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the development of tissue oxidative damage in a wide variety of respiratory and cardiovascular disorders including sepsis and sepsis-associated acute respiratory distress syndrome (ARDS). We examined whether single nucleotide polymorphisms (SNPs) in the XDH gene (encoding XOR) might influence susceptibility to and outcome in patients with sepsis.

Methods

We genotyped 28 tag SNPs in XDH gene in the CELEG cohort, including 621 European American (EA) and 353 African American (AA) sepsis patients. Serum XOR activity was measured in a subset of CELEG subjects. Additionally, we assessed the functional effects of XDH variants utilizing empirical

SUBMITTER: Gao L 

PROVIDER: S-EPMC10324226 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature