Identification of Immune Infiltration in Odontogenic Keratocyst by Integrated Bioinformatics Analysis.

ABSTRACT:

Background

Odontogenic keratocyst (OKC) is a relatively common odontogenic lesion characterized by local invasion in the maxillary and mandibular bones. In the pathological tissue slices of OKC, immune cell infiltrations are frequently observed. However, the immune cell profile and the molecular mechanism for immune cell infiltration of OKC are still unclear. We aimed to explore the immune cell profile of OKC and to explore the potential pathogenesis for immune cell infiltration in OKC.

Methods

The microarray dataset GSE38494 including OKC and oral mucosa (OM) samples were obtained from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) in OKC were analyzed by R software. The hub genes of OKC were performed by protein-protein interaction (P

SUBMITTER: Zhong NN 

PROVIDER: S-EPMC10324234 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature