Visit-to-visit HbA1c variability is associated with aortic stiffness progression in participants with type 2 diabetes.

ABSTRACT:

Background

Glycemic variability plays an important role in the development of cardiovascular disease (CVD). This study aims to determine whether long-term visit-to-visit glycemic variability is associated with aortic stiffness progression in participants with type 2 diabetes (T2D).

Methods

Prospective data were obtained from 2115 T2D participants in the National Metabolic Management Center (MMC) from June 2017 to December 2022. Two brachial-ankle pulse wave velocity (ba-PWV) measurements were performed to assess aortic stiffness over a mean follow-up period of 2.6 years. A multivariate latent class growth mixed model was applied to identify trajectories of blood glucose. Logistic regression models were used to determine the odds ratio (OR) for aortic stiffness associated wit

SUBMITTER: Fang Q 

PROVIDER: S-EPMC10324236 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature