Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study.

ABSTRACT:

Background

The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D binding protein (VDBP). Polymorphisms in VDR or VDBP genes may affect vitamin D levels, influencing the pathogenesis of asthma and atopy. The aim of this study was to investigate the possible association of VDR and VDBP gene single-nucleotide polymorphisms (SNP), 25-hydroxyvitamin D (25(OH)D), blood eosinophils and total IgE level in subjects with asthma in comparison with healthy individuals.

Methods

This case-control study enrolled 63 subjects with asthma (45 allergic and 18 non-allergic) and 32 healthy subjects were involved in the study. Sensitization of subjects to inhaled allergens was determined by a skin prick test, lung function was evaluated by spirometry.

SUBMITTER: Bastyte D 

PROVIDER: S-EPMC10324267 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature