Microstructural Alterations in Projection and Association Fibers in Neonatal Hypoxia-Ischemia.

ABSTRACT:

Background

Diffusion MRI (dMRI) is known to be sensitive to hypoxic-ischemic encephalopathy (HIE). However, existing dMRI studies used simple diffusion tensor metrics and focused only on a few selected cerebral regions, which cannot provide a comprehensive picture of microstructural injury.

Purpose

To systematically characterize the microstructural alterations in mild, moderate, and severe HIE neonates compared to healthy neonates with advanced dMRI using region of interest (ROI), tract, and fixel-based analyses.

Study type

Prospective.

Population

A total of 42 neonates (24 males and 18 females).

Field strength/sequence

3-T, diffusion-weighted echo-planar imaging.

Assessment

Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10324281 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature