Carbon Dioxide, Blood Pressure, and Perioperative Stroke: A Retrospective Case-Control Study.

ABSTRACT:

Background

The relationship between intraoperative physiology and postoperative stroke is incompletely understood. Preliminary data suggest that either hypo- or hypercapnia coupled with reduced cerebrovascular inflow (e.g., due to hypotension) can lead to ischemia. This study tested the hypothesis that the combination of intraoperative hypotension and either hypo- or hypercarbia is associated with postoperative ischemic stroke.

Methods

We conducted a retrospective, case-control study via the Multicenter Perioperative Outcomes Group. Noncardiac, nonintracranial, and nonmajor vascular surgical cases (18 yr or older) were extracted from five major academic centers between January 2004 and December 2015. Ischemic stroke cases were identified via manual chart review and matched t

SUBMITTER: Vlisides PE 

PROVIDER: S-EPMC10324342 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature