Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease.

ABSTRACT:

Background

Neuroinflammation has been widely accepted as a cause of the degenerative process. Increasing interest has been devoted to developing intervening therapeutics for preventing neuroinflammation in Parkinson's disease (PD). It is well known that virus infections, including DNA viruses, are associated with an increased risk of PD. In addition, damaged or dying dopaminergic neurons can release dsDNA during PD progression. However, the role of cGAS, a cytosolic dsDNA sensor, in PD progression remains unclear.

Methods

Adult male wild-type mice and age-matched male cGAS knockout (cGas^-/- ) mice were treated with MPTP to induce neurotoxic PD model, and then behavioral tests, immunohistochemistry, and ELISA were conducted to compare disease phenotype. Chimeric mi

SUBMITTER: Ma C 

PROVIDER: S-EPMC10324349 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature