Fronto-parieto-subthalamic activity decodes motor status in Parkinson's disease.

ABSTRACT:

Aims

Patients with Parkinson's disease (PD) have various motor difficulties, including standing up, gait initiation and freezing of gait. These abnormalities are associated with cortico-subthalamic dysfunction. We aimed to reveal the characteristics of cortico-subthalamic activity in PD patients during different motor statuses.

Methods

Potentials were recorded in the superior parietal lobule (SPL), the primary motor cortex (M1), premotor cortex (PMC), and the bilateral subthalamic nucleus (STN) in 18 freely walking patients while sitting, standing, walking, dual-task walking, and freezing in medication "off" (Moff) and "on" (Mon) states. Different motor status activities were compared in band power, and a machine learning classifier was used to differentiate the motor status

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10324359 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature