Effects of memantine on mania-like phenotypes exhibited by Drosophila Shaker mutants.

ABSTRACT:

Introduction

Increased glutamate levels and electrolytic fluctuations have been observed in acutely manic patients. Despite some efficacy of the non-competitive NMDA receptor antagonist memantine (Mem), such as antidepressant-like and mood-stabilizer drugs in clinical studies, its specific mechanisms of action are still uncertain. The present study aims to better characterize the Drosophila melanogaster fly Shaker mutants (SH), as a translational model of manic episodes within bipolar disorder in humans, and to investigate the potential anti-manic properties of Mem.

Methods and results

Our findings showed typical behavioral abnormalities in SH, which mirrored with the overexpression of NMDAR-NR1 protein subunit, matched well to glutamate up-regulation. Such molecular feature

SUBMITTER: Mocci I 

PROVIDER: S-EPMC10324369 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature