Radiotherapy and radio-sensitization in H3^K27M -mutated diffuse midline gliomas.

ABSTRACT:

Background

H3^K27M mutated diffuse midline gliomas (DMGs) are extremely aggressive and the leading cause of cancer-related deaths in pediatric brain tumors with 5-year survival <1%. Radiotherapy is the only established adjuvant treatment of H3^K27M DMGs; however, the radio-resistance is commonly observed.

Methods

We summarized current understandings of the molecular responses of H3^K27M DMGs to radiotherapy and provide crucial insights into current advances in radiosensitivity enhancement.

Results

Ionizing radiation (IR) can mainly inhibit tumor cell growth by inducing DNA damage regulated by the cell cycle checkpoints and DNA damage repair (DDR) system. In H3K27M DMGs, the aberrant genetic and epigenetic changes, stemness genotype, and e

SUBMITTER: Liu C 

PROVIDER: S-EPMC10324372 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature