Strain-level screening of human gut microbes identifies Blautia producta as a new anti-hyperlipidemic probiotic.

ABSTRACT: Compelling evidence has tightly linked gut microbiota with host metabolism homeostasis and inspired novel therapeutic potentials against metabolic diseases (e.g., hyperlipidemia). However, the regulatory profile of individual bacterial species and strain on lipid homeostasis remains largely unknown. Herein, we performed a large-scale screening of 2250 human gut bacterial strains (186 species) for the lipid-decreasing activity. Different strains in the same species usually displayed distinct lipid-modulatory actions, showing evident strain-specificity. Among the tested strains, Blautia producta exhibited the most potency to suppress cellular lipid accumulation and effectively ameliorated hyperlipidemia in high fat diet (HFD)-feeding mice. Taking a joint comparative approach of pharma

SUBMITTER: Xu W 

PROVIDER: S-EPMC10324434 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature