No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees.

ABSTRACT: Background: War-related trauma is associated with varying posttraumatic stress disorder (PTSD) prevalence rates in refugees. In PTSD development, differential DNA methylation (DNAm) levels associated with trauma exposure might be involved in risk versus resilience processes. Studies investigating DNAm profiles related to trauma exposure and PTSD among refugees remain sparse.Objective: The present epigenome-wide association study investigated associations between war-related trauma, PTSD, and altered DNAm patterns in Burundian refugee families with 110 children and their 207 female and male caregivers.Method: War-related trauma load and PTSD symptom severity were assessed in structured clinical interviews with standardised instruments. Epigenome-wide DNAm levels were qu

SUBMITTER: Mattonet K 

PROVIDER: S-EPMC10324453 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature