Computational formulation study of insulin on biodegradable polymers.

ABSTRACT: Insulin administered orally has a limited therapeutic profile due to factors such as digestion enzymes, pH, temperature, and acidic conditions in the gastrointestinal tract. Type 1 diabetes patients are typically restricted to use intradermal insulin injections to manage their blood sugar levels as oral administration is not available. Research has shown that polymers could enhance the oral bioavailability of therapeutic biologicals, but traditional methods for developing suitable polymers are time-consuming and resource-intensive. Although computational formulations can be used to identify the best polymers more quickly. The true potential of biological formulations has not been fully explored due to a lack of benchmarking studies. Therefore, molecular modelling techniques were used as a

SUBMITTER: Devaraji V 

PROVIDER: S-EPMC10324461 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature