Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip.

ABSTRACT:

Background

Induced pluripotent stem cells (iPSCs) show great ability to differentiate into any tissue, making them attractive candidates for pathophysiological investigations. The rise of organ-on-a-chip technology in the past century has introduced a novel way to make in vitro cell cultures that more closely resemble their in vivo environments, both structural and functionally. The literature still lacks consensus on the best conditions to mimic the blood-brain barrier (BBB) for drug screening and other personalized therapies. The development of models based on BBB-on-a-chip using iPSCs is promising and is a potential alternative to the use of animals in research.

Aim

To analyze the literature for BBB models on-a-chip involving iPSCs, describe the microdevices

SUBMITTER: Alves ADH 

PROVIDER: S-EPMC10324508 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature