Structure similarity and molecular networking analysis for the discovery of polyphenol biotransformation products of gut microbes.

ABSTRACT: Intestinal bacteria can metabolize polyphenols into highly bioavailable derivatives, which provide potential health-promoting effects to the host. However, the metabolic pathways and related products in this process are still largely unclear. Polyphenols are generally characterized by the presence of many phenolic structural units, which makes it possible to explore correlations among compounds based on similar molecular networks. In this study, we developed a standard-oriented/database-assisted molecular networking (SODA-MN) method for iterative compound annotation analysis to explore the metabolic profiles of polyphenol-rich black raspberry extract metabolized by representative gut bacteria. Starting from a group of polyphenol metabolites, the SODA-MN method predicted the possible polyph

SUBMITTER: Xu R 

PROVIDER: S-EPMC10324525 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature