Green tea extract alters gut microbiota and their metabolism of adults with metabolic syndrome in a host-free human colonic model.

ABSTRACT:

Background

Metabolic syndrome (MetS) is a common metatoblic disorder that leads to various adverse health outcomes such as diabetes and cardiovascular diseases (CVDs). Recent studies suggested that MetS-associated gut dysbiosis could exacerbate MetS related diseases. Green tea, a popular beverage rich in polyphenols, has showed antioxidant and anti-inflammatory effects in treating MetS through gut modulation.

Objectives

This study aimed to understand the impact of green tea extract (GTE) on the composition and metabolism of gut microbiota from people with MetS.

Methods

We utilized an in-vitro human colonic model (HCM) to specifically investigate the host-free interactions between GTE and gut microbiota of MetS adults. Fresh fecal samples donated by three adults with M

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10324538 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature