Block Copolymer Micellization of DNA Origami Promotes Solubility in Organic Solvents.

ABSTRACT: The DNA origami technique allows the precise synthesis of complex, biocompatible nanomaterials containing small molecules, biomolecules, and inorganic nanoparticles. The negatively charged phosphates in the backbone make DNA highly water-soluble and require salts to shield its electrostatic repulsion. DNA origamis are therefore not soluble in most organic solvents. While this is not problematic for applications in biochemistry, biophysics, or nanomedicine, other potential applications, processes, and substrates are incompatible with saline solutions, which include the synthesis of many nanomaterials, and reactions in templated synthesis, the operation of nanoelectronic devices, or semiconductor fabrication. To overcome this limitation, we coated DNA origami with amphiphilic poly(ethylene g

SUBMITTER: Agarwal NP 

PROVIDER: S-EPMC10324883 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature