The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Objective

The aim of this study was to examine if the intestinal microbiome is causally correlated with osteoarthritis (OA) incidence.

Methods

A two-sample Mendelian randomization (MR) study was conducted using inverse variance weighting (IVW), weighted median, and MR-Egger regression techniques Publicly accessible summary statistics dataset of intestinal microbiomes of European descent from genome-wide association studies (GWASs) (a total with 3,326 individuals) was used as an exposure As an outcome, summary data from the GWAS include 3,498 patients with OA of the knee and hip from the arcOGEN sample and 11,009 controls of European descent.

Results

We identified 29 single-nucleotide polymorphisms from GWAS of intestinal microbiomes as instrumental variables The IVW a

SUBMITTER: Lee YH 

PROVIDER: S-EPMC10324885 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature