Mendelian Randomization Research on the Relationship Between Rheumatoid Arthritis and Systemic Lupus Erythematosus and the Risk of Autistic Spectrum Disorder.

ABSTRACT:

Objective

The purpose of this study was to examine whether there is a causal link between rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and autism spectrum disorder (ASD).

Methods

We used inverse variance weighted (IVW), weighted median, and MR-Egger regression methods to perform two-sample Mendelian randomization (MR) study using publicly available summary statistics datasets In addition, we employed genome-wide association studies (GWASs) for RA and SLE as exposure and an ASD GWAS as an outcome.

Results

Thirty-three and 28 single-nucleotide polymorphisms from RA and SLE GWASs were selected as instrumental variables for ASD The IVW method revealed no evidence supporting a causal association between RA and SLE and risk for ASD (beta=-0077, standard e

SUBMITTER: Lee YH 

PROVIDER: S-EPMC10324916 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature