Timesweeper: accurately identifying selective sweeps using population genomic time series.

ABSTRACT: Despite decades of research, identifying selective sweeps, the genomic footprints of positive selection, remains a core problem in population genetics. Of the myriad methods that have been developed to tackle this task, few are designed to leverage the potential of genomic time-series data. This is because in most population genetic studies of natural populations, only a single period of time can be sampled. Recent advancements in sequencing technology, including improvements in extracting and sequencing ancient DNA, have made repeated samplings of a population possible, allowing for more direct analysis of recent evolutionary dynamics. Serial sampling of organisms with shorter generation times has also become more feasible due to improvements in the cost and throughput of sequencing. With

SUBMITTER: Whitehouse LS 

PROVIDER: S-EPMC10324941 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature