Association between gut microbiota and primary ovarian insufficiency: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Recent studies have indicated a potential correlation between intestinal bacteria and primary ovarian insufficiency (POI). However, the causal relationship between the gut microbiota (GM) and POI remains unclear.

Methods

A bidirectional two-sample Mendelian randomization (MR) study was conducted to investigate the relationship between the GM and POI. Data on the GM were based on the MiBioGen consortium's summary statistics from the most comprehensive genome-wide association study meta-analysis to date (n=13,266), and POI data were obtained from the R8 release of the FinnGen consortium, containing a total of 424 cases and 181,796 controls. A variety of analytical methods, including inverse variance weighting, maximum likelihood, MR-Egger, weighted median, and const

SUBMITTER: Wang J 

PROVIDER: S-EPMC10324962 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature