Structured cerebellar connectivity supports resilient pattern separation.

ABSTRACT: The cerebellum is thought to help detect and correct errors between intended and executed commands^1,2 and is critical for social behaviours, cognition and emotion^3-6. Computations for motor control must be performed quickly to correct errors in real time and should be sensitive to small differences between patterns for fine error correction while being resilient to noise⁷. Influential theories of cerebellar information processing have largely assumed random network connectivity, which increases the encoding capacity of the network's first layer^8-13. However, maximizing encoding capacity reduces the resilience to noise⁷. To understand how neuronal circuits address this fundamental trade-off, we mapped the feedforward connectivity in the

SUBMITTER: Nguyen TM 

PROVIDER: S-EPMC10324966 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature