Genome-wide by environment interaction studies of maternal smoking and educational score in UK biobank.

ABSTRACT:

Purpose

This study aimed to investigate the associations between maternal smoking (MS) and education score in adult offspring.

Methods

To better understand this link, we performed a two-stage genome-wide by environment interaction studies (GWEIS) of MS and offspring education score in UK Biobank cohort. Specifically, 276 996 subjects from England were enrolled in the discovery study, while 24 355 subjects from Scotland and 14 526 subjects from Wales were enrolled in the replication study. GWEIS were conducted by PLINK 2.0 with MS used as an environmental risk factor.

Results

Significant GWEIS associations ( P  < 0.0001) between MS and offspring education score in both the discovery cohort and two replicate cohorts (Scotland population and Wales population) were identi

SUBMITTER: Huang H 

PROVIDER: S-EPMC10325563 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature