Nonclassical monocytes potentiate anti-tumoral CD8⁺ T cell responses in the lungs.

ABSTRACT: CD8⁺ T cells drive anti-cancer immunity in response to antigen-presenting cells such as dendritic cells and subpopulations of monocytes and macrophages. While CD14⁺ classical monocytes modulate CD8⁺ T cell responses, the contributions of CD16⁺ nonclassical monocytes to this process remain unclear. Herein we explored the role of nonclassical monocytes in CD8⁺ T cell activation by utilizing E2-deficient (E2^-/-) mice that lack nonclassical monocytes. During early metastatic seeding, modeled by B16F10-OVA cancer cells injected into E2^-/- mice, we noted lower CD8⁺ effector memory and effector T cell frequencies within the lungs as well as in lung-draining mediastinal lymph nodes in the E2^-/- mice.

SUBMITTER: Padgett LE 

PROVIDER: S-EPMC10325638 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature