Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study.

ABSTRACT:

Background

Meningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear.

Method

Mendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data. It's a simple but powerful framework, that uses genetics to study aspects of human biology. Modern methods of MR make the process more robust by exploiting the many genetic variants that may exist for a given hypothesis. In this paper, MR is applied to understand the causal relationship between exposure and disease outcome.

Results

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10325787 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature