Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats.

ABSTRACT:

Introduction

Psilocybin is one of the most extensively studied psychedelic drugs with a broad therapeutic potential. Despite the fact that its psychoactivity is mainly attributed to the agonism at 5-HT_2A receptors, it has high binding affinity also to 5-HT_2C and 5-HT_1A receptors and indirectly modulates the dopaminergic system. Psilocybin and its active metabolite psilocin, as well as other serotonergic psychedelics, induce broadband desynchronization and disconnection in EEG in humans as well as in animals. The contribution of serotonergic and dopaminergic mechanisms underlying these changes is not clear. The present study thus aims to elucidate the pharmacological mechanisms underlying psilocin-induced broadband desynchronization and disconnection

SUBMITTER: Tyls F 

PROVIDER: S-EPMC10325866 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature